Muscle contraction is required for vital bodily functions such as breathing, heart contractility, and movement. It is based on the interaction between two filamentous systems: the thick (myosin) and the thin (actin) filaments. This interaction is regulated by Ca2+ and myosin-binding protein C (cMyBP-C). We use state-of-the-art cryo-electron microscopy and computational approaches to study the regulation of thin filaments by Ca2+ and cMyBP-C in order to reveal molecular mechanisms that underlie heart diseases. Our studies pave the way for new therapeutic approaches and drug discovery. We are looking for a postdoctoral fellow who either has experience working with muscle proteins or has training in high-resolution cryo-EM.
Image analysis of cryo-EM images of thin filaments, their complexes with cMyBP-C, or pathogenic variants. Purification of thin filaments, preparation of samples fror cryo-EM
Education and/or training: PhD
Level and type of experience: experience working with muscle proteins or training in high-resolution cryo-EM
Specific knowledge, skills, and abilities: knowledge of the structure of cardiac muscle and its components, experience in biochemistry or biophysical approaches to muscle proteins; and/or experience in cryo-EM, RELION, Cryo-SPARC, PHENIX, Chimera
Other: knowledge of modeling and MDS is a plus
This position is being filled through the Research Foundation, which is a separate entity from Old Dominion University (ODU). While we work in support of ODU, the Research Foundation operates independently and is a not-for-profit, tax-exempt 501(c)(3) organization.
To apply: click Job Browsing; and follow the link for position #26-046. Review of applications will begin immediately and will continue until the position is filled
The organization is an equal opportunity and affirmative action employer (AA/EOE/M/F/Disability/VETS/Drug-Free Workplace). We are committed to providing equal employment opportunity to all individuals in accordance with applicable federal, state, and local laws. Employment decisions — including recruitment, hiring, training, compensation, and promotion — are made without regard to race, color, religion, sex, national origin, physical or mental disability, genetic information, age, protected veteran status, or any other protected characteristic. Affirmative action efforts are conducted consistent with applicable laws to promote equal opportunity in employment and advancement.
As part of our commitment to pay transparency and compliance with applicable laws, the Research Foundation includes a good-faith salary range in all job postings. These ranges represent the expected hiring range for the position, not the full compensation band.
Final salary offers may vary depending on factors such as experience, qualifications, skills, internal equity, and budget availability. The anticipated salary range for this position is: $60,000.00 to $70,000.00
